Short-term antibiotic prophylaxis in open urologic surgery.
J Chemother. 1990 Aug;2(4):257-9.
Pacelli F, Ceriati F, Bellantone R, Cavicchioni C.
Istituto di Patologia Speciale Chirurgica, Universita Cattolica del S. Cuore, Rome, Italy.
The aim of the present study was to compare the efficacy of a single dose of ceftriaxone with a triple dose of gentamicin as prophylactic agents in patients undergoing open urologic surgery. Fifty-two patients were allocated into two groups which were well matched with respect to sex, age and surgical procedure: –24 were given single-dose ceftriaxone (2 g i.v.) at the time of anesthesia (ceftriaxone group); –28 received gentamicin (80 mg i.v.) at the time of anesthesia and two additional doses of the same antibiotic were subsequently administrated every 8 hours (gentamicin group). The incidence of urinary tract infection (UTI) was 3.5% in the gentamicin group and 0% in the ceftriaxone group (p = n.s.); postoperative fever (greater than 38 degrees C) occurred in 28.3% and 8.3% in the gentamicin and ceftriaxone groups respectively (p = n.s.). There was no clinical or hematological evidence of drug side effects in any patient. Results of the study show that short-term antibiotic regimens can improve UTI rates after open urologic surgery; moreover a single preoperative dose of ceftriaxone resulted to be as effective as three doses of gentamicin.
 |
